SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma

histiocytoma, high-grade osteosarcoma, and fibrosarcoma may be artificial. All but one patient tested negative for SATB2; in that case, variable weak to

The utility of SATB2 expression in osteosarcomas and other bone and soft tissue tumours is an useful adjunct to histopathology in diagnosing these rare lesions. A 69 year old male, presented with scrotal swelling since 8 months. Objective: To investigate the role of SATB2 in the pathological diagnosis and differential diagnosis of osteosarcoma. Methods: Immunostaining of SATB2 was performed in 47 cases of osteosarcomas, 5 Osteosarcoma (OSA) is the most common primary malignant bone tumor, usually arising in the long bones of children and young adults. There are different subtypes of OSA, among which we find the conventional OS (also called medullary or central osteosarcoma) which has a high grade of malignancy and an incidence of 80%. 2020-01-31 · The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma.

Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of bone, for instance Ewing sarcoma family of tumors (ESFT), it has not been tested in a large series of ESFT and chondrosarcomas so far. SATB2 is a highly sensitive marker for osteosarcomatous differentiation in gynecologic tract carcinosarcoma, and is also highly specific when used to differentiate osteosarcoma from chondrosarcoma and rhabdomyosarcoma elements in these tumors. The sensitivity of SATB2 for osteosarcoma was 94%, and the specificity was 55%. Stronger-intensity staining was observed in osteosarcoma (P < 0.0001). Conclusions: SATB2 is a sensitive marker for osteosarcoma; however, it is not specific, with expression being observed in other high-grade primary bone sarcomas. SATB2 was a very sensitive marker for osteosarcoma: 100% on whole slides, and 94%, including tissue micro-array (TMA) data, as reported by David and Horvai.

Learn about bone cancer and find information on how we care for people with Apr 15, 2021 Osteosarcoma and undifferentiated pleomorphic sarcoma (UPS) (formerly called malignant fibrous histiocytoma [MFH]) of bone treatment av C Lindskog Bergström · 2013 · Citerat av 1 — and SATB2) proved to be significantly differentially expressed on the tumor suppressor, down-regulated in e.g. osteosarcoma and gastric av I Lundberg · 2017 — osteosarcomas. Oncogene 31, 2270-2282 (2012).

235 products Anti-SATB2 antibodies are offered by a number of suppliers. This target gene encodes the protein 'SATB homeobox 2' in humans and may also be

Dehydroandrographolide Inhibits Osteosarcoma Cell Growth and Metastasis by Targeting SATB2-mediated EMT Anti-Cancer Agents in Medicinal Chemistry, Vol. 19, No. 14 Satb2 regulates proliferation and nuclear integrity of pre-osteoblasts For confirmation, immunohistochemistry for SATB2, a marker of osteoblastic differentiation, was carried out. SATB2 was diffusely immunopositive in the nuclei of tumor cells [Figure 2f]. A final diagnosis of an osteoblastic osteosarcoma was made. The patient was advised chemo and radiotherapy and was discharged.

Osteosarcoma (OSA) is the most common primary malignant bone tumor, usually arising in the long bones of children and young adults. There are different subtypes of OSA, among which we find the conventional OS (also called medullary or central osteosarcoma) which has a high grade of malignancy and an incidence of 80%.

doi: 10.2174/1871520619666190705121614. [Epub ahead of print] Dehydroandrographolide Inhibits Osteosarcoma Cell Growth and Metastasis by Targeting SATB2-Mediated EMT. CONCLUSIONS: SATB2 plays an important role in regulating osteosarcoma stem cell-like properties and tumor growth. The combination of conventional chemotherapy and metformin may be a promising therapeutic strategy for os-teosarcoma patients. Key Words: Cancer stem cells, Chemoresistance, Metformin, N-cadherin, Osteosarcoma, SATB2, Tumorigenesis. SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma Creytens, David MD, PhD *,† Author Information The Role of SATB2 as a Diagnostic Marker for Tumors of Colorectal Origin: Results of a Pathology-Based Clinical Prospective Study. Am J Clin Pathol. 2014 May;141(5):630-8.

This is the first report, where we have documented the increased expression of SATB2-AS1 in osteosarcoma patients and in human osteosarcoma cancer cell lines (U2OS, HOS, MG63). SATB2-AS1 expression was significantly higher in the metastatic tumors compared to non-metastatic tumors.
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Ewing sarcoma (may be in differential with small cell osteosarcoma): Negative for SATB2 Contains a characteristic gene rearrangement (EWSR1-ETS transcription factor) Osteochondroma (may be in differential with parosteal osteosarcoma): Bone contiguous with native marrow Osteosarcoma (OS) is the most common malignant bone tumor and the majority of recurrences are due to metastasis. However, the molecular mechanisms that regulate OS metastatic spread are largely SATB2 positivity was present in 30/50 (60%) cases lacking osteosarcoma, predominantly as patchy moderate staining within undifferentiated sarcoma. No cases showed SATB2 positivity in chondrosarcoma or rhabdomyosarcoma components. 2012-05-16 · Defects in SATB2 are a cause of cleft palate isolated (CPI) [MIM:119540]. A congenital fissure of the soft and/or hard palate, due to faulty fusion.

SATB2 is commonly expressed in osteosarcomas.
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It is relatively rare among domestic animals, but corresponds to 85% of all malignant bone tumors in dogs. To study canine osteosarcoma in animals living in Brazil

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SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma Creytens, David MD, PhD *,† Author Information

(5,37) 2. SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumors. Head and neck 1. SATB2 acts as a tumor suppressor in laryngeal squamous cell carcinoma wherein loss of expression was associated with recurrence and high tumor grade. (36,58) 2.

In addition, SATB2-AS1 is specifically involved in the PI3K-Akt signaling pathway, which can affect the epithelial–mesenchymal transition in numerous ways to influence tumor aggressiveness . SATB2-AS1 was reported as overexpressed in osteosarcoma, and was associated with increased cell proliferation and growth .

SATB2 is a marker of osteoblastic differentiation in benign and malignant mesenchymal tumours. Although SATB2 is not specific for osteosarcoma, it has the potential to be a useful adjunct in some settings, particularly in the distinction between hyalinized collagen and osteoid. SATB2 is commonly expressed in osteosarcomas.

All osteosarcomas were positive for SATB2 in both single cells and multinucleated cells with variable expression for CD68 and MITF. Only 1 out of 5 cases was positive (more than 50% of cells) for Small round cell osteosarcoma is a very rare type of osteosarcoma, histologically mimicking other small round cell malignancies of bone, most notably Ewing sarcoma.To distinguish small cell osteosarcoma from other primary small cell malignancies of bone, we evaluated the immunohistochemical (IHC) expression of CD99 and SATB2, a marker of osteoblastic differentiation. Diagnosing extra skeletal osteosarcomas at rare sites can be quite challenging as it might mimic hyalinized stroma. The utility of SATB2 expression in osteosarcomas and other bone and soft tissue tumours is an useful adjunct to histopathology in diagnosing these rare lesions. A 69 year old male, presented with scrotal swelling since 8 months.